ࡱ> 9 R6bjbj6blzzz8ld|"$n X͜i͜Z6ZZZ(ZZ8ZI]  e8zE:L0|ŘYZ,{Nz 1uWndBR ,gzp 1uWtvNu:gtSegn 1uW[:gSO;mRvq_T 1uWndBRvW,gi_ @wu}Tyf[vޘSU\ VNHarmanN1956t^cQN1uWf[0f[􋤋:N 1uW;eQu}T'YRP[ b~~~ހ_c$O /f_w:gSOpv9h,gSV _N/fS$vI{v`'`uuv͑wV vQ-Nv‰pegYv[@bf0 1uWFree radical /fNSOu}T;mR-NTyuSS^v-NN"Nir wQ gؚ^vSf[;m'` /f:gSO gHev2_|~ N~cN[4ls^ROq_T:gSOvu}T;mR0FO1uWNuǏY NSe0Wnd [1\O;eQ:gSOQvu}T'YRP[ir(STy~ހhV b:gSO(WRP[4ls^0~ހ4ls^S~~hV[4ls^vTy_c$O R:gSOvpۏ zv^STyuu0 яt^eg VQY[1uWS1uWndBRvxvzASR;mÍ (WT{|ߘTyf[0u}Tyf[S;Sf[fNM| N gYsQN1uWSvQndBRvxvzbS 1uWndBR\O:NR'`ߘTv͑SebRKNN ǏNNe8^m9vߘTegNSOQ1uWvs^a ]S0RߘT%{Qf[[v^l͑Ɖ0 ,{N 1uWt N01uWvNu:gtSegn 1uWSS8nyW [/f1uUS(bSTirvGWˆHomdytic Fission Nuv&^ g*gb[5uP[vSP[bWV0[vUS5uP[ g:_pvM[>PT >PTNNTye_NvQNSP[WV~T b_bf3z[v~g V 1uW^8^;ml b:NYS^v;m'`-NSO0 NSOQv1uWR:N'l1uWT^'l1uW0'l1uW`S;N[0WMO 'Y~`S1uW;`ϑv95%0'l1uWSb'l4yP[O2 0Ǐ'lS"lRP[H2O2 01uWOH 0"lǏ'lWHO2 0pǏ'lWROO 0p'lWRO 0.l'l1uWNO 0Ǐ'lN]xxvONOO 0"lǏ'lSirROOH TUS~`'l1O2 I{ [NS~y:N;m'`'lreactive oxygen species ROS /fNSOQg:N͑v1uW0^'l1uW;N g"l1uWH T g:g1uWR I{0 N 1uWvNu NSO~ހ(Wck8^vN"Ǐ z-N bS0RYLuagNv:RoYؚS'l0ؚ\0bLvBR0b̃BR0@gkBR0BRI{oir ppTIQSf[zzlalgirI{\O(u O:Ro:gSONu;m'`'l1uW0 NSOQvPSS^/f;m'`'l1uWNuv͑_0NSO~ހQvĞ VdT'lSv0ӚǏ'lSirvTNADPH'lSvI{(WۏLvOPSS^e O[Nu'Yϑv1uW-NNir0dvOS^Y uirSOQv^v'lS؏SS^ Y8hĞ }0"l0N@~ }Tkxˆ}vI{US5uP['lSS^_NONu1uW0YLusX Y5uy\TIQRI{_N:Ro:gSONu1uWS^ YRP[-NvqQN.GWˆTsSb_b1uW0 1uWS^S+T3*N6k sS_S0XT~bk6k0S^KNR _S6k`S;N[0WMO S^SO|-Nveu1uWb_bYv_z S^irSm^ؚ0_STvibU\6k:NS^v;NSO wY gQ*N_S1uW(WibU\6kl gm1YbXR HNS^-N1\ gQag0@wS^vۏL SO|-NvS^irSm^egNO 1uWvNx4Yv:gOegY S^^1\egba 1uWeg\ gTS^\Pbk01udkS 1uWS^RRf[ g+RNnfvRP[S^ 1uWSNޏ~ O QsޏS^0 Ǐ'lSir\O:N_SBRSNOS^(WNO)n^ NۏL YgS^SO|-N g1uWndBRX[(W [1\__0WUcIc1uWOibce Nb_b0;m'`:_v1uWndBR;bkޏS^v_Y0V:N'lRP[NY g:girS^eNu1uW 1uWndBRUcIcǏ'l1uW -NeޏS^ ;bk g:girv'lS @bN1uWndBRSy:Nb'lSBR0 N 1uWvegn NSOQyr[v1uW g N Tvegn0 'l4yP[1uWO2 (WvQ-Nnbo@w^8^͑v҉r V:N(WS^z^ NvQNY;m'`-NNirvb_bYNN O2 w\O(u0[/fNĞ VdT'lSv0NADPH'lSvǏvvN5uP[؏S\O(uʑ>ev'lNuvb1u|T8Tˆubv0NSO)R(uv'll-N~ g1%^3%lS:NO2 0 Ǐ'lS"lRP[H2O2 _N/fNy͑v^1uW;m'`ir [f(W;m~ހ-Nibce0Ǐ'lS"lv gHe0W\vQlSb4l ub'l1uW0 1uWOH v;m'`g:_ vQJSpg0O:N10-9y vQNuTŏwS^0(W\~I{ؚ\ N ǏSOQ4lvGWˆ\O(ub~ё^\PSǏ z1uQnvǏ'lS"lRP[b_b0+}Y~\Ǐ'lS"lRP[Rˆb$N*N1uWRP[0 Ǐ'lW1uWvJSpgk Spey (Wuir|~-Nibcev_vS_0(W(Ǐ'lSǏ z-N NY NqTxScN*N"lSP[_Y b_bǏ'lW1uW01uW/TRُNS^Ǐ z0 (Ǐ'lS\O(uۏNekNup'l1uWRO T g:gv"lǏ'lSirROOH TS͑cb:NQǏ'lSir-NNir 6qTRˆNuYN0 US~`RP['l1O2 /fSNy^1uWv;m'`ir S/fSOQv~~f2NIQ-Nb_bv0vQJSpg0O:N10-6y wQSOeSQNhTVW(v'`(0[ǏlyvQoS`ϑbǏSf[~TNvQ[RP[vN\O(u0US~`RP['lOHQSuSf[S^vv:NS.MO0 'lS.l1uWNO _N/fNy_͑v1uW [/f|(lx(Wv\O(u Nb_bvNyOSSTir ~g_@\{s^n 2bk@\gvQƖ N MNO@S0_NSǏo;mSNR~MQuv]U~ހ Nu0[vJSpg:N6^50y _[fN'lSuS^ S^NirNO2_N/f1uW0[؏NuirRP[vcS^bNO2 ~Tb_bǏ'lN]xxvONOO 0NOǏYONu~ހk'`0 N01uW[:gSOu}T;mRvq_T 1uW/fSOQTyuSS^v-NN"Nir (WNSOvu}T;mRǏ z-N TyuSS^ N{/fvOS^؏/f^vOS^ ONuTy1uW0N1uWvSf[~gSN wQ [+T g*gM[v5uP[ /fN{|wQ gؚ^Sf[;m'`vir(0(Wck8^v`Q N SOQ1uWYN NeNuNndvR`s^aKN-N v^(WN"-NS%c@w͑\O(u SNNNvTMRRz }vTb X:_}v~ހTlV;m'` cؚ@g̃HegI{0FO/f Yg1uWǏYbndǏba RO[NSO b%N͑qS[0 N 1uWygvuirf[R 1uW\O:NNSOck8^vN"Nir [~c:gSOvck8^N" gyr[vOۏ\O(u0ُyOۏ\O(u;Nhs(W[:gSOqS[irv2_\O(u0 1X:_}v~ހvTlVR cؚ@g̃Heg }v~ހ(WTlV~̃vǏ z-N ['lvmϑoX ONu'YϑvO2 TH2O2 $NǏHaber-Weiss S^؏OۏNekNuOH ُN;m'`'l[uS̃ g_:_v@gmpHeg0OH؏S_STlV~̃v NqTxM M~NirNN_N/fNy:_R@g̃BR N~̃{kN0 2OۏMRRz }vTb MRRz }/fNSOQvNy͑vo } [NuVpx:NMRqir( ~ NYv|~PS'lSub vQuirTb_-N_{ g'l1uWOHbO2 vSN0 3SNR'lvvub @\gR'lv\O(uNuVpxub1 2-"lǏ'lS-5 8 11 14-xVpx12-HPETE SvQNvsQvSTir {|STir/fN|RwQ g:_uirf[;m'`STirY}v Np vMRSO0(WHPETEb_bǏ z-N g;m'`'l1uWSN0 4SNSˆ}vvTb Sˆ}vvMRSOySSˆ}v0SSˆ}v-Nv/(lxTV(lx~SvvS\O(u/fSSˆ}vTbvsQ.ek0(WdkvOSǏ z-N O2 0H2O2 0OHb 1O2I{;m'`'l1uWvSN0 5SNvk\O(u :gSO[Yegkirvk\O(u;N(WۏL k\O(u[(/f(W_|SO~ހr } P450PS N[T{|kirvS\O(u0N[BRϑVQvYegkirSSv^cQSOY [bk\O(u S_BRϑ'Ye :gSOS NOO1\OQs-Nk0(WkǏ z-N ޏcN~ހr } NvO2 1uW/fwckwS\O(uvir(0 6SRQ@vSvTb Q@vS/fQ@vvMRSO0(WQ@vSTbǏ z-N vQMRSOˆ}v((lWzv10*N7(lxkW~ǏvOS\O(ulS:N10*N-W7(lxkW b_bQ@vS0勧SǏ zN'l1uW[RvsQ l g'l1uWvSR 1\ Nb_bQ@vS0 7SN@{X~g_ M@S NO/f|(lx(Wv\O(u Nb_bvNyOSSTir ؏\O:N~ހ~g_VP[ ~g_@{X MNO@S0@{ib _BRYYNpƀxI{ /TRN*NSSO (WNOTbvPSTNADPHSN N 'lSL-|(lxv̀WubNOv^ʑ>e0R~ހY0c@w;mSSn'`xsSv O@{s^nN@\g-NvcGMP4ls^XR N Oۏ@{s^n~g_ b6R@\gQZT|D0RQv~ހ N0 8@g$OYeg_uirT$v~ހ NOTO2 ~TNTubONOO 4yP[ (WeuؚNutpHvx'`agN NvS_3z[ N AQvQ1uubMOnibcely0R܏vMOn0Ne(WNONutpHvx'`agN NutagN N__Ydk ONOO zsSRubNOTO2 ُ$Ny1uWv'lS'`^8^:_ wQ g_'Yv~ހk'` [N@g$OYeg_uirT$v~ހ^8^ gaIN0 6q (Wu}T;mR-N 1uN~8^S0RTyYLu NoV }v:Ro [:gSO~~-Nv1uWpeϑ__ǏY u[:gSO~~NuqS[0 N 1uW[u}T'YRP[v_c[ 1uWwQ gؚ^v;ml'`Tg:_v'lSS^R Ǐ'lS\O(u;eQSOQvu}T'YRP[ Y8hx0ˆ}v(0|{|T(I{ OُNir(SuǏ'lSS'`0NTTeˆ N _w~ހ~gTRv4xOW [:gSOv~~4xOWTL'`SS0 OH /fg;mlv1uW _N/fk'`g'Yv1uW0[ST;m~ހ-NvNUORP[SuS^ b_c$O NS^^g_ 4xOWvRP[MS|{|0(lWx0x08hT g:gxI{0 O2 vk'`/f:gSOSu'l-Nkv;NSV 1u[_wv_c$Ohs(WO8hxeˆ0Y|ZS NqTxǏ'lS\O(u ۏ b_c$O0~|SO'lSxxS\O(uv9eSSvQNN|RvSS0 @b gNu O2 vuir|~ǏgkSS^ub H2O2 O\pevv-SH]W 'lS1Y;m0V:NH2O2ŏzǏ~ހ O2 N (W~ހQvH2O2NFe2+ bCu2+ yP[S^ubOH SY+}Y~_NOH2O2GWˆubOH ُ/fH2O2k'`vwckSV0 11uW[8hxv_c[ 1uW\O(uN8hx{|ir(O_wN|RvSf[SS0OY (lWbWv1d0xWN8h|ޏcveˆ08h|v'lSTxx(.veˆI{0S^؏Ob_bev1uW SuޏS^ [8hxxW4xOW NuW OzS %N͑S_cv NO Y [~ހ{kN0 21uW[ˆ}v(v_c[ 1uWSvc\O(uNˆ}v( _NSǏ{|Ǐ'lSNirc\O(uNˆ}v( Nu4xOW\O(u0YǏ'l1uWROO SOˆ}v(RP[SuNT ubS'`vؚZir vQN1uWRSOˆ}v(vYeˆ v^O*N+R(lWxSuSf[SS0f%N͑v/f 1uWS9eSvˆ}vvSf[~g [vuir;m'`v'N1Y0 31uW[|{|v_c[ 1uWǏ'lS'`MOY|eˆ Yq_T m-NvY| N q_T'Yvck8^R01uWO8h|01'l8h|b_b1"l1uW [DNA;NeˆbxW4xOW ؏SO~ހ[|-N|RP[W'lS ub NqTvWbZTbSZir N 4xOW~ހ NvY|~g q_T~ހMQuRvS%c0 41uW[(v_c[ (-NvY NqTx1uN+T gY*NS. Sf['`(;ml gfS1uWv4xOW SuǏ'lSS^0x/fgbuirv͑R V[+TY NqTxEegfS1uW4xOW0-NxSuǏ'lS\O(u O_w-Nˆ}v(SvvNTb1Y;m [􁜁'`vSS %N͑q_TvTyutR0N~ހhVx@b+Tv NqTxk(v؏Y @bN[Ǐ'lSS^f:NOea0Yg~ހQ~|SO'lSS_c ROOϑub|~S0Rq_T0nvSOS0R4xOWROʑ>eQvQ-Nv4lv| OO~ހQYyir(4l %N͑euO b~ހꁶn ~~OW{k01udkS 1uW[uirv4xOW_%N͑ 1\O_w~ހRvg'Y }qN0  N 1uWf[ NN9hnc[p:gtv N Tt cQNYypf[ ;N g1uWf[0MQuR NMf[0-N_f[0N"1Yf[0uirpf[0 }Npf[0pǏ z-NWVm]VP[SvQWVh9eSvf[I{01uWf[knZi0Wʑ:gSOpǏ z-Nvyyur Yt^e0v~SMQuR NMI{ /fvMRg g gRvf[0 1uWf[􋤋:N 1uWv:_'lS\O(u _c$ON:gSOvu}T'YRP[ _wNSO~ހMQuTSOmMQuvRQ1_ g~[MQuuuvQs0vQ\O(u:gtSib:NN NQ*Neb0 1u}T'YRP[vNTZTT }v/}y 1uW\O(uN(SuǏ'lSS^ vQ'lSv~NirNNI{O_wˆ}v(08hxI{u}T'YRP[vNTZT b_b }01uN } NnN4l @bN N@w:gSOvN"cQSOY (W~ހQnXy0vQ|HTWb_b-iWb_ v_~:N1~5_s| |'Y\Ot^vX'Y X'Y0t^e1\/f1u }(WvvXy b_bv t^evQs/fNSOpvN*Nf>fvYha_0SY @wSˆ}vvNTZT OOSˆ}vn'` NM09_'`MNOS4lTRQ1_ O[v1YS _R v~XY t^(QuRQ1_I{0 }(W~ހ-NvXy OQs_RvQbOzfRSux uQst^'`uFTu0eNˆ}v4lv{| [N[~~v_c$O4xOW N _w~/el{Tl{v4xˆ lby)\ hTV@mNKNlSONbcϑQ\ [􁺀l0 ck8^`Q N ~~~ހvˆ}vvNbˆ}vvYOcs^a ˆ}vvb6RBRc6R@w4lˆ}vv{|vʑ>eN;m'`0Yg:ONُyb6RBR 1\ gS[􁺀l0g8TeQpSvQN'Yl-Nvalgir OO-N'l1uWXY O4lˆ}vvXYTO4lˆ}vvv)Y6qb6RBR1Y;m g~[􁺀lvQs0 41uWN:@T͑LpAm_c$O :@@b_wv~~_c$O/f{k'`uuv;NSV0 gYncf (W[hQ'`:@0:'le ~~_c$O z^{ (W:@TQLple 1uN1uWv%`gRXY O~~_c$OfR%N͑0 (W:@T͑LpAmr` N ~ހQv'l1uW;NegĞ VdT'lSv [/f1uMRSOĞ VdT1"lvlS egv01"lv^lX[(WNTy~~~ހ-N [/fNNAD+:N5uP[cSSO @bN NNu1uW0S_~~~ހ:@e ATPubϑQ\ [~ހQϑ N N~cck8^vyP[Sm^0N/f Ca++͑eR^O_~ހQCa++Sm^X'Y o;mNNyˆ}vv \1"lv NS0WlSb'lSv0SY :@O_~ހQATPQ\ AMPXY AMPSSekRb!kĞ VdT !kĞ VdT/f'lSvv[\O(u^ir0S_͑LpAme 'lRP[͑eۏeQ~~ N~~-Ny/}v!kĞ VdTT'lSvSuS^ ub'Yϑv;m'`'l1uW0ُN;mlN g:_'lS'`v1uWO~ހ(Ǐ'lS Of(xTSˆ}vM N 9eSN~ހv~gNR b~~v NS_c$O0SY (W:@~~-NwQ gnd1uWvb'lSv{|TbRSux N RgRN1uW[:@T͑LpAm~~v_c$O0 51uWNe ۏ @g$O~~~ހ b0ov4xOW [puTsQp0 71uWN+@ +@vQs_NN1uW gsQ0ncxvzhf 0W-Nwm+@vutSSS+T~~ހvǏ'lS NY NqTx+TϑQ\ -SHlSb-S-SWVT~u }E+TϑQ\0:'`+@vuSǏ z_N g1uWSN V:Ndke~~ހv~u }ETǏ'lSv+TϑQ\ f1uW4xOW )w[}T0 81uWNkvu gsQxvzf kvu;mR4O g;mÍv1uWS^0nd1uW ;e1uWS^[kvuv2Tlu gN[\O(u01uWS^(WkvuSu-Nv\O(uevS0R͑Ɖ0 vMR:N t^'`KN1uWS_csQ|[R1uWN|?\u_N gk YBgvsQ|'YuNKQq\u_N g[RvsQ|0@w1uWtvxvzSU\ YN{|͑'YuuN1uWS^vsQ|ck(Wekc:y01uW[N{|eP^vq_T\O(uck(WfYvN@bcS egYvN[ck(WЏ(u1uWt (WnxONSOeP^ebvxvz-NS_'Yvbg0 1uWndBR N01uWndBR{N 1uW/fNSOck8^vN"Nir ck8^`Q NNSOQ1uW/fYN NeNuNndvR`s^a-N NSOQX[(W\ϑv'l1uW NFO[NSO NgbZ NSNOۏ~ހXk :Ro}v~ހTTlV~ހ@gmp~̃ mdpu Rkir0FOYgNSOQ1uWvpeϑǏY 1\O[uirTvQN~~ b_c$O 4xOW~ހ~g r^pbNSOvck8^N";mR _wuu RNSOpۏ z0 (WgvۏSǏ z-N u}T g:gSOQ_6qONuNNir(ndُN1uW \[N~y:N1uWndBRScavenger 0 1uWndBR/fcnd1uWb;e1uWSNv'lSS^vir(01uWndBRvy{|A~Y SR:Nv{|ndBRT^v{|ndBR$N'Y{|0v{|ndBRN,:Nb'lSv ;N g'lSirgkSvSOD 0Ǐ'lS"lvCAT 07uǏ'lSirvGPX I{Qy0^v{|1uWndBRN,SbĞn{|0Y|{|0~u }C 0~u }E0-\S }T؏SW7uGSH I{;m'`{|0 1uWndBR'YY:Nb'lSBR Ǐnd\O(uMNO;ml1uW-NSOSm^ MNO1uWޏS^-NibU\6kvHesegc6R1uWvub0FO gNb'lSBR/fǏb6R1uW_SBRYgNё^\CQ } vNu w\O(uv01uWndBR_N N/fb'lSBR gN|~v^*gۏL'lS\O(u0 1uWndBRS%c\O(u_{n N*NagN,{N 1uWndBR gN[vSm^,{N V:N1uW;ml'`g:_ NeNul N1\ONDяvu}T'YRP[w\O(u @bN1uWndBR_{(W1uWDя v^NNg_v^bHQN1uW~T &TR1\w N0R^ gvHeg,{ N (W'YYpe`Q N ndBRN1uWS^TOSbev1uW ُ*Nev1uWvk'`^\NSeg1uWvk'`Mb g2_\O(u0 ُN1uWndBR[~c:gSOvck8^u}T;mR OceP^w@w͑v\O(u0FO/f @wt^vX :gSOQNu1uWndBRvRn NM N Q1_N[1uW_c[v2_R O:gSO~~hV[[fS_c RN:gSOvp _SN|Rvuu0:NN2bkdk{|savSu SNN:N0W1uߘeEQ1uWndBR N 0R2_uu0^pvvv0 N0v{|1uWndBR N 'lSirgkSvsuperoxide dismutase SOD 'lSirgkSvSOD /fvMRxvz_gmeQ0^(u_g^lvNyv{|1uWndBR0 1y{|0~gSR^ 1968t^ VNMcCord(W Fridovichc[ N N[r~~ހ-NcSCuZnvvˆ}v( v^Ss[PSO2 gkS @bNbُyvˆ}v}T T:N'lSirgkSv e{y:NSOD0 SODX[(WNQNN@b g`'l|T8TvuirSOQ Sb~̃0w̃0ؚI{ iir0ؚI{RirTNSO-N0SOD/fN{|+Tё^\vv cvQ@b+Tё^\W N TSR:N+Tܔ SODCuZn-SOD 0+T0SODMn-SOD T+TSODFe-SOD 3y0 +Tܔ ё^\WvCuZn-SOD/fg:N8^vNyv ;NX[(WNw8h~ހv~ހ(-NbؚI{ iirvS~SOW(0{|VSOQNS~|SO-N0(WRir@m0[r0*s0[r_0LF0SI{R iir~~-NGW gX[(W /fvMR^(ug^lvN{|v0v1u$Nag~b kag+T gܔ0 SP[TN*N ;m'`-N_v8h_/fܔ0 Fe-SOD;NX[(WNS8h~ހ-N NNw8h{|uؚI{ iirYOg0gj0juI{~~Q_N gX[(W0dkv_N1u$Nag~b N,k*NNZSO+T gN*NSP[0 Mn-SOD;NX[(WNS8h~ހTw8h~ހv~|SO-N (W iirvS~SOW(0{|VSOQ_NOX[(W (WNSO-N+Tϑؚ0dkvv~THT|~r 1u$NagbVag~b0 2tSSuirf[yr'` SOD^\x'`ˆ}vv [pH0pTˆ}vv4lI{S^kN,v3z[0S1uNSOD^\Nё^\v vQ'`( NNSQNˆ}v( ؏SQN~T0R;m'`MOvё^\yP[0 N{|SODv;m'`-N_+T gё^\yP[0YǑ(uirtbSf[eldSё^\yP[ Rv;m'N1YY͑eR Nё^\yP[ Rv;mSb` Y0 N TegnvCuZn-SODwQ gؚv Tn'` [NvirSyr'`_N_veu@bSv'Yϑ1uW N Q\>e\[NSOvQNck8^~~v_c$O Q{LvuI{$v`>eSuevuSoR\O(u 5 mduR X:_[gRpЏRv^R0 Vdk wQ gnd1uWRvSOD1\b:N;Sf[0ߘTTu}Tyf[I{Wxvzvpp0 vMR SOD]^l0W^(uNNNu;mvT*Neb0YmSsY'`m9U1rvSYT-N g'Y[SOD0^YSOD 0SOD ^BRI{0SODmRNSYT gf>fv2RfHegTbp\O(u S gHe2bkvS5uy\Y+}Y~ v_c$O0 SOD(W;Su Nv^(uf/f N܀g>N [$\vQ[lusQpT{|Θn'`sQpuHe>fW0dkY SOD[luLvu0:@T͑LpAm_c$O0l0}vQ0|?\u0+@I{uuGW guHe0 SOD(WߘTebv^(u_Ng:N^l S\O:NR'`ߘTvRVP[bߘT%{Q:_SBR go}Yvbp0bp0b\0buRI{OeP:_vHeg0VYbSOD\O:NߘTmRBR^(u0RS|Tne-N0VQ_N_SQNYy:_SSODvߘT YSOD|0SODFvY0SODdUR0SODgAlne0SODvxvYTSODS gmI{0؏S(u[+TSODvSeR]6RbR'`ߘT Y'Yne0:RhSODAlI{0(WNNegl͑eP^nߘvN)Y SOD\b:NRߘT-Nv;mÍRP[0 6q SOD\O:NN{|ؚRP[b'lSv RP[ϑ(W32000S\N N S&^ gё^\W NvQegn'YYNRir@*s@0[r@ TRirhVNSgN_uir-N6RY eg Y:Nuiry^\]__'Yv_n'`ˆ}v0Vdk (W^(u N [dNwQ g%Nfv NoS^'`SS 6 [v~ހbvMOvNTRNO o(uT'` Nf>f0Vdk [uuvuHe:ONyr_'`\O(u 7 vv3z['` Nؚ [tSV }:NOea Ǐؚ)n^0Ǐ'YBRϑ\0ǏeXl0Ǐ:_xx^0ǏYSf[ir(SS'`BR0؏SBRI{GWf[SODRP[~g9eS v;m'`'N1Y b_b NS'`SS 8 oir\O(uUSN'`'Y08^ĉBRϑUSrO(uuHe ksO0 [SOD^(uǏ z-N[‰X[(Wv@\P'` VQYf[ۏLN'YϑSS gbHevxvz]\O v^]ekc"}b[~bQ㉳Q N@\PvNN gHeelT[V{0 4 SODv6RY SOD^lX[(WNR0 iirT_uirSOQ FOvMRbV;N/fNRir@m-NcS0S0R@nT_svP6R q_TNSODvuNb,gTc^^(u0 1uN)R(u_uirm~uk uNSODwQ gfW{Q0f'Yĉ!j]NSuN0 NSc[N6qagNP6RI{O'` Vdk _uirSODvubwQ gf^vSU\MRof0vQ]zAm zY N ̃SOW{Q!4xX!̃SO4xGr ! Rnasev0y_30R ! nm! NDE32g ! 0.2mol/L NaClm1 ! m1m! R45%NH4 2SO40y_ ! Nnm ! NDE32g ! m1 ! m1m! Sm)! QQr^q! SODbT0 4x̃velSǑ(uXlYtl0vˆl0~ހꁶnl0/lN-YNlT2ulI{09hnc gsQvxvzhf (u2ul4xX[cSukSODwQ gN[vO'`0SY :NNcؚSOD~^ (Wm1eSǑ(uh^m1l0 5SODv~^hg SODNTN,:NEm~rQr^| vQ~^vhg;N9hncN N N*Nch0 1 GWN'` 8^(uZNppQ5ulhgvQGWN'`0_NS(uf:yN[vĉ_ NySOD gyr[v8T6eIQ1 ‰[~vv8T6eIQ1 gRN$ReSODv~^0 6SODv;m'`Km[ Rgel N,R:NvclTcl$N'Y{|0 vcl__d\O YBg0Nfr3z[ ͑ Y'`}Y NyrkՋBRSNhVY TN,[[Ǒ(u FOuir7hT8^O br^pb 2 Sf[SIQl s|luminol (WN[agN NNH2O2SCo2+I{ё^\yP[qQX[eSQ:_pv݄IQ S_7hT-N gCATX[(We W(vH2O2\R 1uH2O2@b_wvSf[SIQ:_^Q1_ 1udk{;`CATv;m'`0Sf[SIQlfSՋBRM6R0d\Ob/gTagNSKm[eI{YyV }q_T FO~Ǐel9eۏ ScdTy NoV }[Km[vq_T /fNy{USupOe0͑ Y'`}Y0yr_'`_NؚvSf[SIQb/gKm[el 3 g1l nm-N$N*N5ugRNN[v5uSgS5uS TNuSKm5uAm g1l/f^(u'l5ug ǏKmϑُy5u5uAmϑNKm[n(vel0S_S^SO|-N+T gN[Sm^vǏ'lS"le ReQN[ϑv+T gǏ'lS"lvv7hT Ǐ'lS"l1\R Nu'll U_N NS>f:yQS^[-N'lϑXR XRv z^NReQmSO-Nvv;m'`bckk0勹el^l(uNuSebvxvz]\O 4 n[l Sb:`$Ǐ|xxv^irl(W-N'`4lnm-N CATPSǏ|xxv؏Sb|xxv TeʑQ'l0~ǏN[eT ReQkxxOv1Y;m N-NbkS^ (uؚ0xnmn[kX[vǏ|xxv ~gS fCAT;m'`a$Ǐ'lS"ln[lN[ϑv~̃ TN[ϑvH2O2SuS^ ~ǏN[eTRx-NbkS^ 6qT(uؚ0xn[iRYOvH2O2ϑ N Km[~̃Ǐ'lS"lvv;m'`0 5 hSKm[l (WN[pHvQm-N Ǐ'lS"lv\O(uNǏ'lS"lʑQ'll0dkS^^8^ŏ0gRp (W Nedb0aSQSvagN N @bNuv'll_Nŏ8Qnm (WN[[ϑv[hVQNuSRSS SRSSpefvnd\O(u0 ?Q6 }/fN6S-NcSQegvYZ{|STir-6YZTea Polyphenols {yTP v;NSObR ~`S6YZ;`ϑv60%^80% 6r^͑v12%^24%0\O:N6YZ-N+Tϑgؚ0ot\O(ugf>fv~R ]_wN^lv͑Ɖ0'YϑSOY[SRirՋ[ ?Q6 }wQ gb'lS0b$v0bR |7hlxS02\02b0bnu0bǏOeSb̃bukI{\O(u /fNyOov)Y6qb'l1uWndBR06YZnmnd1uW;m'`'YNVCnm06YZ:N1uWndBR 6YZv;NbR?Q6 }(Wnd1uWǏ z-NnboN͑v҉r0'Yϑvxvzhf?Q6 }'lSZTir_N/fNy gHev1uWndBRTb'lSBR wQ gbLv0bzS0b̃0buk 9eUTlu_@{uu lu|?\uI{YyutR0vQ(WߘT0;SoOePI{Wv\O(uegzQ0\O:N?Q6 }'lSZTirv6r }luQ_uv\O(u:g6R(WNcؚSOD;mRTMNOMDA+Tϑ JR1_(Ǐ'lS\O(u XRO'lTO@R06r }[ؚ@Sv2T\O(u_N/fǏcؚSOD;mR0X:_:gSOvb'lSR [sv0 SR }/fNyYZ{|STir ُySTir(Wx'`N(-NRpGWNuR } Ee\ُ{|ir(}T T:NSR }0SR }/f1u N Tpeϑv?Q6 }bh?Q6 })T b RNZSO0 NZSOvASZSO0NVZSO:NNOZSO NZSON N:NؚZSO vQ-NNZSOR^g^0SR }/fNy)Y6q gHev1uWndBR ;NX[(WNa0g0SSF0q\ i0u0Og0e~g0WIlg0}vhgh0:Ru0juTg0ΑI0ؚhI{ iir-N0dkY aAl0~aR0gAl0]KQRTdUR-N_N+T gSR }0SR }Y:N4lbYNcSir \pe~yP[Nbc~S (uQQbUr^qbmhr|+g sTm eu g0RyTvSR }NZSO0 NZSOSNndTy'l1uW N wQ gb'lS0M@S0bLvI{Yyot;m'` X:_MQu0buR0^pI{RHe0 _Ğn{|\O:NNy gHevb'lSBRVQY] g_YbS0'Yϑ[xvz~ghf_Ğn/fNy gHevb'lSBRT1uWndBR0  N _ϑCQ } dN NvTyvS~u }{|0Ğn{|STir Y_ϑCQ }_Nw0Rnd1uWv\O(u0 1.Rx Rx/fNy^8^͑v_ϑCQ } /fRx7uǏ'lSvv;m'`bR Se-GPXX[(WNހFmT~|SOW(-N O gkvǏ'lSir؏SbekvWSTir v^OǏ'lS"lRbT4l DdeQRx NeOSe-GPXv;mR NM (WSOQYNNORx4ls^e Se-GPX;mRNRxvDdNϑHTckvsQ FO0RN[4ls^e v;mR NQRx4ls^ NGS NGS0 gNf[|?\u'Y eEQRxT~u }E vQGPXT'lSirgkSvSOD ;m'`GW g N T z^XR (Ǐ'lSNirNN+TϑKN NM S/fV:Nb'lSvˆ}vNa|v|SS^S0RRxT~u }Evb6R Ob'lSv;m'`_0ROb0SY ؚ|sX-NXRv|WSˆ}vOꁨR'lSNu'Yϑ1uW _wN|Rޏ'lSǏ z RxT~u }Evb'lS'`S;eُNǏ z-NvgNs0 2. (Wnd1uWvǏ z-N_Nw0R_͑v\O(u0 Q\yP[ۏeQ~ހv^b6RvQ(W1uW_Sv_S^-NvPS\O(u _N~bk1uW_wv(Ǐ'lS_S^0 SNzNN b6RN(Ǐ'lSvY*Ns [NǏzNNhb~TvMOp SO YTirNuQ\ ǏHater-WeissS^NuOHQ\ b{|lS:N;m'`'lv_S^b6R0: ؏SN>fWMNOGPXv;m'`01uN SNo;mSOQvGPX :ONOSOQ g;m'`vGPXpeϑQ\ _N1uN :ON[vǏ'lS(ubXY OGPXmXY [vQ;m'` NM0 ؏ g3z[~ހv\O(u 1uN N~~ހ~T b6RN(Ǐ'lSǏ z-N@bNuv1uW N MNON1uW[v_c$O0 \O:N'lSirgkSvvv PS'lyP[SugkSS^0 :ONSN>fWMNOCu/Zn-SODv;m'` OMn-SOD;m'`NP'`GSؚ0FOS_: %N͑e Mn-SOD;m'`vNP'`GSؚN6q[1uW gb6R\O(u NSm^XR b6RX:_0 SN[SOQkxˆ}vvNu b6R1uWv_c[ Nb'lSBR̜T vQb'lS\O(uX:_0 3.ܔ Cu/Zn-SODv;m'`-N_/fܔ ܔ݄ˆ}v-N+T g@nܔv'YR /f~ހYm͑vb'lSBR0ܔ݄ˆ}vvb'lS\O(u;N/f2bkǏ!nё^\Fe2 TCu2 PSH2O2b_bOH0ܔ݄ˆ}vwQ g'lSvv;mR \Fe2 'lSbFe3 2bkFentonS^vSu0 4. /fǏ'lS"lvCAT v;m'`-N_ SOQ NRKNNvX[(WN@~ˆ}v-N @~ }:ON CAT;m'` NM0FO;m'`/f(Ǐ'lSvPSBR (Ǐ'lS/TRS^@bNuvpWN'lS^ NupǏ'lW0ُN1uWQ^\O(uN( OS^N_ NeۏL (Ǐ'lWv'`(^8^;mÍ b~ހbRv_c[0 5.0 0/fSOQYyvv~bbR NSOQYvv;m'` gsQ00Nܔ T7h/f'lSirgkSvSOD v͑~bbR (Wnd'lSir0X:_:gSOMQuRebNuq_T0Mn-SOD/fSOQ1uWndBR0[Neg ڀ΀Teu?QSOQvMn-SOD+TϑؚNbt^N @w:gSOp vQ+Tϑek NM0t^r }e-N }(W~ހQvb_bTZƖNMn-SOD gsQ0Vdk 0vbp\O(u;NNSOQMn-SOD gsQ0 6. g:gMNO(Ǐ'lS Ob~ހ( MNO@Fm00I{~~-NǏ'lS(4ls^0 V {|\S } V0[+T1uWndBRvߘT @wNN[1uWtvN egYvN_YsQlYnd1uWvRߘT0ߘTN[N_N[dkۏLNygvxvzTc"}0vMR [dk{|ߘTvxvz'Y g$N*NeT0N/fN)Y6qR i-NcS gHebR mRNTynebV`ߘT-N\O:NR'`ߘTvRVP[bߘT%{Q:_SBR0vMR] gmRSODvˆĞq0[rvY0Sn'`TaU0dUR0}vR0gAlne0wl4l0vY|0x[rsN0Qn{|I{{|WvR'`ߘTb^0N/f)R(u_uirSub~ހW{Q _0R1uWndBR+Tϑ0N[vNT0 (WY)Y6qR iir-N+T gb1uWv;m'`bR0YY+T%cSlTY } vQbN gYZ0YnTYpZ0~6v;NbR6YZ Og0zSv gHebRĞnTZ{| TygT,܃-Nv~u } ؏ gNN-NoY}vLN0NsTP[0[9h0\SsY0g0fMRP[I{_N+T gYy;m'`bR0SY ZQS0upI{w̃-NvY|_N/f gHev;m'`bR0(WRirvI{hV[ @m-N_NScS gsQv;m'`bR0 )R(u_uirSub~ހW{QuNRVP[ _N/fvMRxvzvpp0Y(WVSOW{QW NN]WQkYI 1uYtv'YF~\b[9h wgV`Suub9N_Ğn (u'Y~ހW{Qbm~ukuNSOD0ُNel NSlP0c[vP6R S[s]NSvޏ~uN0 NASNN~ g)RNnxON{|eP^vR'`ߘT\/fߘTLNSU\v͑p0sQN1uWndBRvmeQxvz [2TluN{|vYuu NS[T{|OePߘTuNebGWwQ gc[aIN0@wxvzvmeQ \ gfYf gHev1uWndBR_ST)R(u \OۏNekcRR'`ߘTLNTMRSU\ :NON{|vSOeP^\OQf'Y!.s0 ` 1uWtv8h_Q[/fNHN 1uW[NSO gTNqS[`7hmdbQ\ُNqS[ NHNS1uWndBRT gTNy{| SOD(WߘT-N gTN^(u _ϑCQ }N1uWndBR gNHNsQ| Se.s 1 N^tqI{. 'l1uWndBRv^(u. uirf[Bg_, 2002, 19(4):52~58 u[.'l1uWT)Y6qb'lSBR.SN:yf[QHr>y,1999 ѐ^N.R'`ߘT.SN:-NV{]QHr>y,1995 ߏCNsI{. SODvSf[yr'`SvQ^(u. l3QN'Yf[f[b,1999, 302 : 171~175 hT VO. pv1uWf[Nbp-Novxvz.)Y%mof[. 1997,9(2): 47~49 N }I{.)Y6qߘTb'lSBRNNv%{QNeP^.lSQN'Yf[f[b,1998,21(1):110~114 jly[. )Y6qb'lSBRv_S)R(u.^{]N,1999,2:22~23 s%fI{. 9N_Ğnvb'lS\O(u.WSNQN'Yf[f[b,1998, 212 :104~108 Y~(gI{. QyĞn{|STirnd;m'`'lv[xvz.,{NQ;S'Yf[f[b,1997,184 : 363~365 !u.6YZvcST^(uxvzۏU\.sNS],1999,19(3):34~36 _I{. zS gHebRTb;m'`'l1uWHevxvz. zP[xvzGl R,1996,7, 15(2):154~162 Ng%fI{. ?Q6 }'lSZTNirot\O(uxvziQ.6SJournal of Tea, 2001,27l :28~34 ss I{.[Rxǃߘ(uQ[\ @n;`'l1uWndRvq_T.ߘTyf[,1998,8:9~10 ѐs,fzb.OgScSirSvQ(WOePߘT-Nv^(u.ߘT]Nyb,1996,(2):47~48 hgwm,gqe.s^ǃY|vRy~SSvQ['l1uWvHe^.ߘTyf[,1999,10:16~18 hgΞfI{. ~u }ETRx[|?\uuSؚ@S_c[eNNS'lSgkSvv\O(u‰[. Nwm;Sf[,2002,25(11):22~26 H,T fI{. 6YZ Oovb'lS1uWndBR.6S,Journal of Tea ,1998,244 :217~218 HYuI{. 6?Q6 }N"RRf[xvzۏU\.6Syf[,2001,211 :11 ~16 __CgI{.uir{|ĞnvxvzS^(uiQ[J].ߘTNSu]N,1999,25(6):52~57 swm[I{.uI gHebRRySvQ[1uWvndR.ߘTN:gh,2000,4:45~47 旉[3I{. _ϑCQ }Rx(W2b1uW_c$O-Nv\O(u. ^N_ϑCQ }yf[,2001, 8(5):25~29 NgNmI{. _ϑCQ } (W2b1uW_c$O-Nv\O(u.^N_ϑCQ }yf[,2001,8(7):47~48 'kNvI{.ߘ~~b'lSTOH1uWnd;m'`vxvz.ߘT]Nyb,1997,5:23~27 3u?I{.a}|Sf[bRRgSb'lS'`(vxvz.ߘT]Nyb,2000,21(2):18~20 NgNSI{. N{|9h{|ߘirb'l1uWvkxvz.ߘTyf[,1998,19(2):12~14 _lI{.ZWg{|ߘirndROOv\O(u.ߘTyf[,2000,21(1):42~43 hgb\,Hf[Oe.-132['l1uWnd\O(uvxvz.sN2;Sf[,1997,24(1):28~30 FLOYD R A, SOONG L M, STUART M A, et al. Spin trapping of free radicals produced from nitrosoamine carcinogens. Photochem photobiol, 1978, 28: 857~863 HEINLE H, KLING D, et al. Oxygen free radical and scavengers in the natural sciences. Budapest: Akade miai Kiado (Publishing House of the Hungarian Academy of Sciences), 1993. 159~165 TOTH E, NGUYEN Thi Ha, et al. Oxygen free radical and scavengers in the natural sciences. Budapest: Akade miai Kiado(Publishing House of the Hungarian Academy of Sciences). 1993. 155~158 TOLLE A, KOLLECK I, et al. Vitamin E metabolism of the lung. Fett Lipid, 1996, 98: 328~331 Mutoh H, Hiraishi H, OTA S, et al. Relationships between metals ions and oxygen free radicals in ethanol induced damage to cultured rat gastric mucosal cells. Digestive Diseases and Sciences. 1995, 40: 2704~2711 TING H H, TI MI MI F K, BOLES K S, et al. Vitamin C improves endothelium dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation, 1996, 97: 22~28 NATVING D O. Human copper zinc superoxide dismutase complements superoxide dismutase deficient E.coli [J]. J Biol Chem, 1986, 261: 9361~9370 DEVECI M, DIBIRDIK I, et al. Alphatocopherol and GinKgo biloba treatment protects lipid per-oxidation during ischemic period in rat groin island skin flaps. European Journal of Plastic Surgery, 1997, 20: 141~144 NIAZ M A, SINGH R B, et al. Effect of antioxidant rich foods on plasma ascorbic acid, cardiac enzyme, and lipid peroxide levels in patients hospitalized with acute myocardial infarction. Journal of the American Dietetic Association, 1995, 95: 775~780 BIACS P A, DAOOD H G, et al. Oxygen free radicals and scavengers in the natural sciences. Budapest: Akade miai Kiado(Publishing House of the Hungarian Academy of Sciences). 1993.307~314 ATTELLA M J, HOFFMAN S W, STASIO M J, et al. GinKgo biloba extract facilitates recovery from penetrating brain injury adult male rats. Exp Neurol, 1989, 105: 62~71 NI Y C, ZHAO B L, HOU J W, et al. Protection of cerebellar neuron by GinKgo biloba extract against apoptosis indured by hydroxyl radicals. Neuron Science Letter, 1996, 214: 115~118 SZELEKOVSZKY S, SIRO B, SZATMARIE, et al. Local treatment of chronic inflammatory conditions with propolis enriched with antiphlogistic trace metal ions. Radicals ions and tissue damage. Budapest: Akademiai Kia does Nyomda Vallalat.1990.257~269 HUANG Kehe, CHEN Wan-feng, HUANG K H, et al. Effect of selenium on the resistance of chickens to Mareks disease and its mode of action. Acta Veterinarian et-Zoo technica Sinica, 1996, 7: 448~455 PAGE  PAGE 13 "npHJ* , . 0 D F H J \ ^ p r t v  D F L  ^`bd  z|V B*o(ph 5\o( OJQJo(H*o(H*o( 5CJ \o(o(CJo( 5CJ\o(R">VnpJ l tDWD``0WD`0$XD2a$WD` & F$a$5Dvh@Phb ,!^WD``0WD`0WD`VXz|~ 4 < > J N R T V X ,!L!$"&"""""###### 5\o(CJo( OJQJo(H*o(o(H*o([,!L! ""r#$$%%&&''&*8*h+,,,../001^ i;VD2WD^i`;WD` WD^`WD`###########$$$$$ $($.$>$B$T$V$X$Z$f$h$p$r$t$v$&&&*8*,,,..002222222333555555555555555667899;;;;;;==Z?B*OJQJo(phB*H*o(ph B*o(ph5o( 5\o( OJQJo(H*o(H*o(o(P1233366*778899:===>Z?l?@@A^ UDWD]`WD`$^a$WD`WD`WD`Z?l???@@@@(@*@,@.@@@ABCCCJJJKKKKKKKKLL,M.MPPQQQQQQQQQQRRRRRPXRX```` ``cccciiiiiiiillmmmmmmmmFnHnJn55o(CJo( 5CJ\o( OJQJo(H*o(H*o( H*aJo(o( 5\o(SABBCCCCC|@|B|D|d}}5o(H*OJQJo(OJQJH*OJQJo(5OJQJ\o(5OJQJo(H*o(H*o(o( OJQJo(N}B~D~ <>@BāƁȁhj*.@BXތ0268<> @BDJNTVXZȣ Ωةکܩީ  "$,.2ܪCJCJo(H*H*OJQJo( 5\o(CJo( 5CJ\o( OJQJo(H*o(H*o(o(QXJbތ`t lxĠ UDWD]`WD`WD``^fȣ 2dȩʩ̩Ωة4pd & F$a$^ & F0WD`0WD`ܪު>@JLNPRVX\^bЫҫDFvz8:46Z\dfxzޱ CJo(CJbdȫnڬ*nή.*ް6dIJrֳ:P$~ & F!"$%)*23;<@AMNZ[deuv´Ŵƴʹδ  !>?HILMPQSTWX^_cdklopz{}~CJo(CJbµõƵǵеѵصٵ۵ܵ $%'(+,12UVabdeklnorsǶȶʶ˶ӶԶ׶ض߶()*+-.0CJo(CJb01346789;<ABCDFGMNUVWX`avwŷƷȷɷѷҷ$%01;<EFOPVW[\]^bchinoCJo(CJbǸȸиѸָ׸ $%,-/078WXYZ\]bcdeghnouvxy¹ù˹̹ҹӹչֹ޹߹ CJo(CJb~SNaV$%&23456&`#$VD^ & F%&./STUVXY^_`acdjkqrvwͺκӺԺֺ׺ںۺw}opwx¼üȼɼ˼̼ԼռټڼCJo(CJb $&/089?@BDEFHIV"#$&'-.012560JmHnHu0J j0JUCJo(CJ84&P 182P. A!n"n#n$n%S  iF@F cke $1$a$$CJKHPJ_HaJmH nHsH tHA@ ؞k=W[SO>T@> eW[WW&UDWVD&WD]^`4C@4 ckeeW[)ۏiJWD^i`J,R@, ckeeW[)ۏ 2 i^i0S@"0 ckeeW[)ۏ 3WD`4 @24 u$ 9r G$a$CJaJ)@A ux6b +78K]S]lH}"y4 | }  [bDPZfYhZdLUZAQirI ! ""X#c####$$ %j%%%F&&'!'<'''(R(g(((N))**+H+++',S,,,--Y--@....."/*///50F0V0111"2>2s22383D33 44 555556677P88899::;4<<<"=E>?]?@!@,@|@%AAB1CCoDzD0EE:GHLJJJJJL LMM^NbNNNOOOOOP{QQRRRRRRRRRRRRS8SRSSSST7TmTTTU7UgUUUV@VoVVVW2WbWWWWX:YYPZ$[[~\S]N^__a`Vabb&b2b3b7b000 0 0 00000000000000000 00000000 0 0 0 0 00000 0 0 0 0 0 0 0 0 0 0  0  0  0  0  0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0  0! 0" 0# 0$ 0% 0& 0'@0@0@0 0 V#Z?Jn}ܪ06aeginortuvwyzD,!1A@N0^nXd~6bdfhjklmpqsx5c !!8@0(  B S  ? *+68GMNRJK \] "#'CDEFMNOPRT\]klstGH-0@Eotwy|}!"xy34;=>?  < > A F K P W ` b w y    ! % ' ( ) * , - 0 5 > g l { }   i k | ~   G I P U [ ] e g %')+Z[ad  )-137;CEOPY[efXZghU[cdsuwy~KMTUYZ@A PQ hjqvHI %!&!1!5!2G2H2N2O2j2k2r2s2u2z2{2222222222222222222222 33333373;3C3D3W3_3b3j3n3s333333333333333 4 44P4T4U4W4\4`4o4s44444444444445 5 5555"5$5158595S5V5Y5[5h5k555555555555566 6"6'6*6-6/65676Z6]6e6g6i6o6v6w6x6|6}666666666666P7S7]7`7t7v7777777777778888"8&8)8,8?8C8O8P888888888Q9W9[9\9999999999999::::":):*:1:5:6:::O:R:Y:]:c:g:y:|:::::;;;;;;;;;;;;<"<3<7<<<><A<C<<<<<<<<<<<<<=== ===!="=2=9=@=C=V=Z=i=o=====>>">&>D>E>>>>>>>>>>>>>>>>>>>>>>>>>??,?/?\?`?h?i?j?k?l?m?x?}??????????????? @ @@@ @"@(@,@u@v@{@|@@@@@$A%AxA{A~AAAAAA3B4BxByBBBBBBBBBBBBBBB0C1C4C5C>C?C@CBCQCTCYCZCmCnCCCCCCCnDpDyDzDDDDDDDEE!E$E/E0EEEEEFF-F0F7G:GMGVGaGdGgGuGxGyG|GGGGGHHHHHHHHHHKJLJJJJJJJJJJJKK-K3KgKhKjKmKvKzKKKKKL L L LLLLLLLLLLLLLdMmMsMuMyMMMMMMMMN!N#N&N)N-N0N2NCNFNJNMNQNWN]N`NaNbNjNnNNNNNNNOO>O@ODO\O^ObOOOOOOOOOOOOOOOOOuPxPPPzQ{QQQQQRRRRRRRRRRRRRRRRRRRSSSSS)S*S,S-S2S8S;SU?UPUQUWUgUjUkUnUoUUUUUUUUUUUUUUUUUUVVV(V)V-V@VDVEVRVVV]VoVsVtVVVVVVVVVVVVVVVVWWWWWWW$W2W6W7WIWJWPWbWfWgWxWyW}WWWWWWWWWWWWWWWWWWWAXMX[XdXeXnXXXXXXXIYLYYYYYYY2Z6ZYZaZZZ+[,[4[6[w[[\\\$\1\;\<\E\P\V\^\b\c\g\\\\\\\\\^^^^^^5_;_<_B_________` `````&a/a0a3a9a?a\a`akaoaaaaaabbbb4b7bjp6; !adLMjk+0LPad # )  f m     ! $ 0 3 } ~ 7 : ~   > A ] ` a b x | Z[-1EF[\mq:@Xbdi]`+2GLMR47:=Z[[\/3QTX^dkMN EKEHbg"&(+=Bpu^ajkNV !!-!.!B!E!S!V!`!c!~!!!!j#k####### $ $ $&$R$X$$$$$$$% %O%R%^%a%%%%%%%%%.&1&>&A&s&v&&&&&&&'''')'.'((1)4)?*F*N*R***7+:+++*,0,,,--@-D-----3.6.@.C.V.Y.s.w.............////0$06070u0{0000000#1%1&1'1g1j1{1~1222222;3?3L3P3s3w33333333444J4N44444555555555555 6 61626F6I6V6Y6666677888888l9m99999999:!:::::::;;;;;;7<;<}<<<<<<<<<<==*=.=O=R===========>>Q>W>>>>>>> ??>?D?H?O?V?[?m?q??????@@@@@@@@@@@@@CCLDMDrDxDzDDDDDDDDEEEEE!E'E*EJEKEYE_EEEEEEEEEEEEEEEEEEEEEEFFFFFFFFFFFHGIGPGQGnGrG}GGGGGGGGGGGG HHHHHHII I#I2JJL LMM^NbNNNOORRRRb4b7bzyg@C:\WINDOWS\Application Data\Microsoft\Word\ ꁨRb` Y OX[,{5z1uWndBR.asdzyg!E:\R'`ߘTfN \R'`ߘTfN?z\,{5z1uWndBR.doczyg!E:\R'`ߘTfN \R'`ߘTfN?z\,{5z1uWndBR.doczyg!E:\R'`ߘTfN \R'`ߘTfN?z\,{5z1uWndBR.doczyg!E:\R'`ߘTfN \R'`ߘTfN?z\,{5z1uWndBR.doczyg!E:\R'`ߘTfN \R'`ߘTfN?z\,{5z1uWndBR.doczyg!E:\R'`ߘTfN \R'`ߘTfN?z\,{5z1uWndBR.doczyg!E:\R'`ߘTfN \R'`ߘTfN?z\,{5z1uWndBR.doc*NN5u!G:\R'`ߘTfN \R'`ߘTfN?z\,{5z1uWndBR.docqiaoE:\1\fN?z?z\R'`ߘT\,{5z1uWndBR.doc:"0W!>*I;hQnt~ \(1|0Z/ 6m\K)$NU)"Y)q~Y$.UK;lj)}=zpEO^oM_CI$P*ZORY) 3qK)*Z?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{}~Root Entry F@381Table|WordDocument6SummaryInformation(DocumentSummaryInformation8CompObjfObjectPool@38@38  FMicrosoft Word ĵ MSWordDocWord.Document.89q